Lipoprotein-associated phospholipase A2 and oxidized low-density lipoprotein in young patients with acute coronary syndrome in China.

摘要: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered to be a risk factor for acute coronary syndrome (ACS), but this remains controversial. This study investigated the role of Lp-PLA2 in young Chinese patients with ACS. 228 (aged ≤55 years) ACS and 237 age-matched controls were included. oxidized low-density lipoprotein (ox-LDL) levels measured by sandwich enzyme-linked immunosorbent assay. significantly correlated smoking, total cholesterol (TC), (LDL-C) ox-LDL (all P < 0.05). Multivariate logistic regression analysis showed that male sex (OR = 3.25, 95%CI = 1.26–8.38), smoking (OR = 3.50, 95%CI = 1.75–7.0), triglyceride (OR = 1.76, 95%CI = 1.08–2.87), high sensitivity C-reactive protein (hs-CRP) (OR = 2.11, 95%CI = 1.14–3.90) (OR = 2.98, 95%CI = 1.72–5.1) independently associated patients. was when adjusted traditional factors, including age, sex, diabetes, hypertension, TC, LDL-C, hs-CRP (OR = 1.98, 95%CI = 1.10–3.56). When further levels, association between became insignificant (OR = 1.69, 95%CI = 0.90–3.17). marker oxidative stress inflammation, rather than an independent