Association Between Single Nucleotide Polymorphisms and Susceptibility for the Development of Adverse Effects Resulting from Radiation Therapy
作者： Barry S. Rosenstein
DOI: 10.1007/978-3-540-76271-3_3
关键词:
摘要: A small, but signifi cant number of radiotherapy patients develop adverse responses to treatment, manifested as either normal tissue/organ damage or the development a radiation-induced cancer. The ability predict which are at greatest risk for radiation toxicity would be great benefi t in optimizing treatment decisions. One promising approach predictive assay is through use genetic information. main source variation among individuals single nucleotide polymorphisms. Much early work identify polymorphisms (SNPs) associated with injury focused on candidate genes. These studies have provided results indicative basis radiosensitivity, it clear that this too limited its scope SNPs could serve clinical applicability.
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