Evolution of DNA binding motifs and operators.

摘要: A gene regulatory protein with helix-turn-helix (HTH) DNA-binding motif, GalS contains a functional operator within the DNA sequences encoding HTH region (Nature 369 (1994) 314). We searched for operator-like binding motifs of other proteins. Five such proteins, DeoR, CytR, LRP, LuxR and PurR, were found to have actual or in motif. Except all them including GalS, are known be auto-regulated. Auto-regulation case DeoR has not been investigated. Seven proteins containing do motif; none them, except MerR, The may evolved from common ancestor site its segment that encodes motif facilitate auto-regulation. discussed current evidence monophyletic polyphyletic origin sequences.