A mild two-step propargylation of aromatic bioactive small molecules
作者： Naoki Kanoh , Toshitaka Okamura , Takahiro Suzuki , Yoshiharu Iwabuchi
DOI: 10.1039/C7OB01587A
关键词:
摘要: A two-step method for introducing a propargyl group in aromatic bioactive small molecules has been developed. This features propargylation of groups using cationic hexacarbonyl complex the presence cesium carbonate, and decomplexation resultant cobalt complexes 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate. These reactions proceed under mild conditions, thus are applicable acid- and/or oxidant-sensitive molecules.
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