Effects of Mycoplasmas on the Host Cell Signaling Pathways

摘要: Mycoplasmas are the smallest free-living organisms. Reduced sizes of their genomes put constraints on ability these bacteria to live autonomously and make them highly dependent nutrients produced by host cells. Importantly, at organism level, mycoplasmal infections may cause pathological changes host, including cancer severe immunological reactions. At molecular mycoplasmas often activate NF-κB (nuclear factor kappa-light-chain-enhancer activated B cells) inflammatory response concomitantly inhibit p53-mediated response, which normally triggers cell cycle apoptosis. Thus, be considered as cancer-associated factors. same time, through membrane lipoproteins (LAMPs) along with lipoprotein derivatives (lipopeptide MALP-2, macrophage-activating lipopeptide-2) able modulate anti-inflammatory responses via nuclear translocation activation Nrf2 (the factor-E2-related transcription 2). interactions between cells multifaceted depend cellular context. In this review, we summarize current information role in affecting host’s intracellular signaling mediated transcriptional factors p53, Nrf2, NF-κB. A better understanding mechanisms underlying pathologic processes associated reprogramming eukaryotic that arise during mycoplasma-host interaction should facilitate development new therapeutic approaches treat oncogenic processes.