Migraine Genes and the Relation to Gender

摘要: Migraine is an episodic brain disorder that characterized by recurrent attacks of severe unilateral headache are accompanied various neurological symptoms. In addition, many patients have what called aura with visual and sensory disturbances. The majority female, suggesting female hormones play important role in the pathophysiology disorder. molecular mechanisms, however, underlying this preponderance not well understood. It can be expected field genetics aims at identifying genetic factors cause migraine lowering threshold for will unravel some these mechanisms. 3 best known genes encode ion transporters were identified families familial hemiplegic (FHM), a rare subtype aura. FHM gene mutations alterations mechanisms control modulate neurotransmitter balance brain. Transgenic mice knock-in human pathogenic shown to exhibit migraine-relevant features very helpful dissecting pointed central cortical glutamate. transgenic overexpress RAMP1 exist increased sensitivity calcitonin gene-related peptide. Findings from animal experiments on gender differences discussed. Recently, glutamate also came forward genome-wide association study common migraine. By deciphering pathways, it near future we better understand behind