A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas.

摘要: Papillary thyroid cancer (PTC) incidence increased dramatically in children after the Chernobyl accident, providing a unique opportunity to investigate molecular features of radiation-induced cancer. In contrast previous studies that included age-related confounding factors, we investigated mRNA expression PTC and normal contralateral tissues patients exposed non-exposed fallout, using age- ethnicity-matched non-irradiated cohorts. Forty-five were analysed by full-genome microarrays. Twenty-two have been fallout; 23 others age-matched resident same regions Ukraine, but born 1 March 1987, is, not 131I. A gene signature 793 probes corresponding 403 genes permitted differentiation between from those who radiation was identified. The differences confirmed quantitative RT-PCR. Many deregulated pathways are related cell proliferation. Our results suggest higher proliferation rate could be either as predisposition or consequence radiation. allows identification cancers.