An Exploratory Analysis of Stream Teratogenicity and Human Health Using Zebrafish Whole-Sediment Toxicity Test

摘要: This study demonstrates a novel application of effect-based toxicity testing for streams that may provide indications co-perturbation to ecological and human health. For this study, sediment contact assay using zebrafish (Danio rerio) embryos was adapted serve as an indicator teratogenic stress within river sediments. Sediment samples were collected from Lake Michigan tributary watersheds. responses then compared prevalence congenital heart disease (CHD) vital statistic birth indicators aggregated civil divisions associated with the Significant risk relationships detected between variation in early life-stage (ELS) endpoints 72 h post-fertilization disease, low birthweight infant mortality. Examination principal components ELS suggests variance related embryo circulatory malformations is most closely CHD prevalence. Though assays are sometimes used prospectively, form investigation can only be conducted retrospectively. These results support hypothesis bioassays normally screening useful environmental humans expand our understanding environmental–human health linkages.