Outcomes and costs of implantable cardioverter-defibrillators for primary prevention of sudden cardiac death among the elderly

作者: Peter W. Groeneveld , Steven A. Farmer , Janice J. Suh , Mary Anne Matta , Feifei Yang

DOI: 10.1016/J.HRTHM.2008.01.038

关键词:

摘要: Background The clinical outcomes and costs of implantable cardioverter-defibrillators (ICDs) used for primary prevention sudden cardiac death in nonexperimental settings are uncertain. Objective purpose this study was to measure the health among a nationally representative cohort elderly, primary-prevention ICD recipients. Methods We collected health-care cost utilization data from all Medicare beneficiaries hospitalized congestive heart failure (CHF) who had received ICDs between October 2003 September 2005 as well propensity-score-matched control CHF during same period. A multivariable Cox proportional hazards model fitted cohort, which comprised 7125 recipients controls followed through December 2005. claims first year inclusive index hospitalization were assess differences costs. Results receipt associated with significant reduction mortality (adjusted hazard ratio=0.62, 95% confidence interval 0.58–0.67). patients higher median hospital 30 days after initial (median difference=$41,542, P Conclusions implantation reduced nonexperimental, patient population CHF. additional substantial but comparable published cost-effectiveness models that have projected be cost-effective.

参考文章(33)
Peter W. Groeneveld, Paul A. Heidenreich, Alan M. Garber, Trends in implantable cardioverter-defibrillator racial disparity: the importance of geography. Journal of the American College of Cardiology. ,vol. 45, pp. 72- 78 ,(2005) , 10.1016/J.JACC.2004.07.061
Andrea B. Parker, Salim Yusuf, C.David Naylor, The relevance of subgroup-specific treatment effects: The Studies Of Left Ventricular Dysfunction (SOLVD) revisited American Heart Journal. ,vol. 144, pp. 941- 947 ,(2002) , 10.1067/MHJ.2002.126446
Paul R. Rosenbaum, Optimal Matching for Observational Studies Journal of the American Statistical Association. ,vol. 84, pp. 1024- 1032 ,(1989) , 10.1080/01621459.1989.10478868
Peter W. Groeneveld, Mary Anne Matta, Janice J. Suh, Paul A. Heidenreich, Judy A. Shea, Costs and Quality-of-Life Effects of Implantable Cardioverter-Defibrillators The American Journal of Cardiology. ,vol. 98, pp. 1409- 1415 ,(2006) , 10.1016/J.AMJCARD.2006.06.041
Rachel M. Werner, David A. Asch, Daniel Polsky, Racial profiling: the unintended consequences of coronary artery bypass graft report cards. Circulation. ,vol. 111, pp. 1257- 1263 ,(2005) , 10.1161/01.CIR.0000157729.59754.09
Gillian D. Sanders, Mark A. Hlatky, Douglas K. Owens, Cost-effectiveness of implantable cardioverter-defibrillators. The New England Journal of Medicine. ,vol. 353, pp. 1471- 1480 ,(2005) , 10.1056/NEJMSA051989
Deborah A. Taira, Todd B. Seto, Richard Siegrist, Roberta Cosgrove, Ronna Berezin, David J. Cohen, Comparison of analytic approaches for the economic evaluation of new technologies alongside multicenter clinical trials American Heart Journal. ,vol. 145, pp. 452- 458 ,(2003) , 10.1067/MHJ.2003.3
Matthew R. Reynolds, David J. Cohen, Aaron D. Kugelmass, Phillip P. Brown, Edmund R. Becker, Steven D. Culler, April W. Simon, The frequency and incremental cost of major complications among medicare beneficiaries receiving implantable cardioverter-defibrillators. Journal of the American College of Cardiology. ,vol. 47, pp. 2493- 2497 ,(2006) , 10.1016/J.JACC.2006.02.049
Paul R. Rosenbaum, Donald B. Rubin, The Bias Due to Incomplete Matching Matched Sampling for Causal Effects. ,vol. 41, pp. 217- 232 ,(1985) , 10.1017/CBO9780511810725.020
Arthur J. Moss, Wojciech Zareba, W. Jackson Hall, Helmut Klein, David J. Wilber, David S. Cannom, James P. Daubert, Steven L. Higgins, Mary W. Brown, Mark L. Andrews, Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. The New England Journal of Medicine. ,vol. 346, pp. 877- 883 ,(2002) , 10.1056/NEJMOA013474