High Rumen-Degradable Starch Diet Promotes Hepatic Lipolysis and Disrupts Enterohepatic Circulation of Bile Acids in Dairy Goats

摘要: BACKGROUND High rumen-degradable starch (RDS) diets decrease milk fat. The increase of LPS in plasma associated with increased RDS impairs liver function, immune response and lipid metabolism, which depress the precursors for OBJECTIVE This study investigated mechanism depression fat small intestine dairy goats fed different diets. METHOD Eighteen Guanzhong lactating (second lactation, 45.8 ± 1.54 kg) 6 ruminally cannulated (aged 2-3 y, 54.0 ± 2.40 kg) were 3 low dietary concentrations 20.52% (LRDS), medium 22.15% (MRDS), high 24.88% (HRDS) 36 21 d, respectively, experiments 1 2. metabolites jejunal microbiota experiment rumen fluid 2 measured. One-way ANOVA was used to analyze biochemical parameters mRNA or protein expression. MIXED procedure concentrations. RESULTS In 1, HRDS diet showed activity alkaline phosphatase (27.4 41.4 U/L) (P   1, P   2.0, P < 0.05) than did LRDS diet. 2, had greater (7.57 13.6 kEU/mL) (0.037 0.179 EU/mL) (P < 0.05) CONCLUSIONS Feeding promoted hepatic β-oxidation disrupted phospholipid bile acids metabolisms liver, thereby reducing supply lipogenic mammary gland goats.