Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.

作者: P G Nishanian , O Martínez-Maza , J F Salazar-Gonzalez , E C Breen , T Kishimoto

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摘要: Polyclonal B cell activation is commonly observed in AIDS and infection with HIV. The effect of HIV on the induction stimulatory factor 2 (BSF-2) production was examined, since BSF-2 plays an essential role differentiation activated cells to Ig-secreting cells. Increased mRNA levels increased secretion were soon after exposure mononuclear isolated from healthy donors both "live" inactivated HIV-induced seen monocyte/macrophages, but not T These results suggest that overproduction might contribute polyclonal

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