A Novel Antiviral Agent Which Inhibits the Endonuclease of Influenza Viruses

摘要: A novel anti-influenza virus compound, flutimide, was identified in extracts of a recently fungal species, Delitschia confertaspora (F. Pelaez, J.D. Polishook, M. Valldosera, and J.Guarro, Mycotaxon 50:115-122, 1994). The substituted 2,6-diketopiperazine, selectively inhibited the cap-dependent transcriptase influenza B viruses had no effect on activities other polymerases. Similar to 4-substituted 2,4-dioxobutanoic acids, series inhibitors which we described previously (J. Tomassini, H. Selnick, M.E. Davies, Armstrong, J. Baldwin, Bourgeois, J.Hastings, D. Hazuda, Lewis, W. McClements, G. Ponticello, E. Radzilowski, Smith, A. Tebben, Wolfe, Antimicrob. Agents Chemother. 38:2827-2837, 1994), this inhibitor, is natural product, affected neither initiation nor elongation mRNA synthesis, but it specifically targeted endonuclease transcriptase. Additionally, compound inhibitory replication cell culture. selective antiviral properties further demonstrate utility as target agents.