Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine
作者： Iva Fernandes , Nuno Vale , Victor de Freitas , Rui Moreira , Nuno Mateus
DOI: 10.1016/J.BMCL.2009.10.081
关键词:
摘要: Abstract The growth inhibitory activity of imidazoquines, antimalarial imidazolidin-4-ones derived from primaquine, on human cancer cell lines HT-29, Caco-2, and MCF-7 has been evaluated. Primaquine, N-dipeptidyl-primaquine derivatives, other quinolines have included in the study for comparison purposes. Primaquine some its derivatives were significantly active against breast line, so these compounds might represent useful leads targeted at development novel specific agents cancer. Conversely, all generally inactive with only one imidazoquines having IC50 below 50 μM. Activities Caco-2 line modest did not follow any defined trend.
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