Steroid hormone receptor profile of premenopausal endometrial polyps.
作者： Zitao Liu , Satu Kuokkanen , Lubna Pal
关键词:
摘要: The etiology and pathogenesis of endometrial polyps (EPs) are only partially understood. To better understand how sex steroids regulate polyp growth, we investigated the messenger RNA (mRNA) expression genes reproductive steroid hormone receptors (estrogen alpha [ERalpha] beta [ERbeta], G protein-coupled receptor 30 [GPR30], progesterone [PR]) in EP tissue autologous normal appearing endometrium (R) Within each patient, remote from site was taken as an internal control. Relative expressions interest within were compared to respective control (i.e. R). R is abbreviation for later calculation formula. Ten patients diagnosed with a tertiary care center included this study. Directed biopsies obtained under hysteroscopy along opposite uterine wall patient. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) used gene profiling paired samples. relative between patient analyzed 2(-DeltaDeltaCt) method. We found that ERalpha, ERbeta, GPR30, PR expressed both showed no difference samples same cavity. However, correlated GPR30 (r = .70, P .023), suggesting co-expression may be contributory mechanism EPs at least subset women.
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