Modeling psychiatric disorders with patient-derived iPSCs.

摘要: Psychiatric disorders are heterogeneous characterized by complex genetics, variable symptomatology, and anatomically distributed pathology, all of which present challenges for effective treatment. Current treatments often blunt tools used to ameliorate the most severe symptoms, at risk disrupting functional neural systems, thus there is a pressing need develop rational therapeutics. Induced pluripotent stem cells (iPSCs) reprogrammed from patient somatic offer an unprecedented opportunity recapitulate both normal pathologic human tissue organ development, provides new approaches understanding disease mechanisms drug discovery with higher predictability their effects in humans. Here we review recent progress using iPSCs modeling neuropsychiatric developing novel therapeutic strategies.