Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells
作者： A Koch , A Völzke , C Wünsche , D Meyer zu Heringdorf , A Huwiler
DOI: 10.1111/J.1476-5381.2012.01824.X
关键词:
摘要: PPARγ agonists [thiazolidinediones (TZDs)] are known to exert anti-fibrotic effects in the kidney. In addition, we previously demonstrated that sphingosine kinase 1 (SK-1) and intracellular sphingosine-1-phosphate (S1P), by reducing expression of connective tissue growth factor (CTGF), have a protective role fibrotic process.
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