The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway under High Glucose Condition
作者： Wei Liu , Xiaochun Liang , Dan Yang
DOI: 10.1155/2015/295135
关键词:
摘要: Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia and series of complications. The Wnt/β-catenin signaling pathway complex protein interaction network, which also key regulator cell proliferation differentiation. Many scholars have found that high glucose can activate the Wnt pathway. However, effects activation this in presence levels during progression diabetes still remained unclear. Here, we provide review study on state signal influence Chinese medicine it.
hindawi.com
core.ac.uk参考文章(41)
Zhao Zhong Chong, Yan Chen Shang, Kenneth Maiese, Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling. Current Neurovascular Research. ,vol. 4, pp. 194- 204 ,(2007) , 10.2174/156720207781387150
石镁虹, 施森, 刘勇, 周翔宇, 曾宏, 何延政, 聂丽霞, 杨辉, 孙晓磊, 钟武, Role of Wnt/β-catenin signaling pathway in impaired wound healing of diabetes mellitus Chinese Journal of Endocrinology and Metabolism. ,vol. 27, pp. 57- 61 ,(2011) , 10.3760/CMA.J.ISSN.1000-6699.2011.01.017
Liem Thanh Tien, Expression of β-catenin in hepatocellular carcinoma World Journal of Gastroenterology. ,vol. 11, pp. 2398- 2401 ,(2005) , 10.3748/WJG.V11.I16.2398
F. Osakada, S. Ooto, T. Akagi, M. Mandai, A. Akaike, M. Takahashi, Wnt Signaling Promotes Regeneration in the Retina of Adult Mammals The Journal of Neuroscience. ,vol. 27, pp. 4210- 4219 ,(2007) , 10.1523/JNEUROSCI.4193-06.2007
Christian Lange, Eilhard Mix, Katja Rateitschak, Arndt Rolfs, Wnt signal pathways and neural stem cell differentiation. Neurodegenerative Diseases. ,vol. 3, pp. 76- 86 ,(2006) , 10.1159/000092097
S. Portal-Núñez, D. Lozano, L. Fernández de Castro, A.R. de Gortázar, X. Nogués, P. Esbrit, Alterations of the Wnt/β-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice FEBS Letters. ,vol. 584, pp. 3095- 3100 ,(2010) , 10.1016/J.FEBSLET.2010.05.047
Tetsu Akiyama, Wnt/beta-catenin signaling. Cytokine & Growth Factor Reviews. ,vol. 11, pp. 273- 282 ,(2000) , 10.1016/S1359-6101(00)00011-3
Hans Clevers, Roel Nusse, Wnt/β-catenin signaling and disease. Cell. ,vol. 149, pp. 1192- 1205 ,(2012) , 10.1016/J.CELL.2012.05.012
Inah Hwang, Eun-young Seo, Hunjoo Ha, Wnt/β-catenin signaling: A novel target for therapeutic intervention of fibrotic kidney disease Archives of Pharmacal Research. ,vol. 32, pp. 1653- 1662 ,(2009) , 10.1007/S12272-009-2200-3
Xiao-Feng Li, Hao Xu, Yong-Jian Zhao, De-Zhi Tang, Guo-Hua Xu, Jonathan Holz, Jing Wang, Shao-Dan Cheng, Qi Shi, Yong-Jun Wang, Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wnt/β-Catenin-BMP Signaling Evidence-based Complementary and Alternative Medicine. ,vol. 2013, pp. 652317- 652317 ,(2013) , 10.1155/2013/652317