Pharmacokinetics of rectal paracetamol after major surgery in children

摘要: Glycogelatin capsular suppositories containing a paracetamol slurry 40 mg.kg-1 were given PR to 20 children (12 months-17 yrs) after major orthopaedic surgery and plasma concentrations of measured for up 18 h. The mean maximum concentration (Cmax) was 0.115 (SD 0.049) mmol.l-1. Peak occurred (Tmax) at 2.3 1.2) Mean 0.07 0.03) mmol.l-1 six Apparent clearance 5.8 ml.min-1.kg-1. associated with analgesic effectiveness in is unknown, but antipyretic effects are seen the range 0.066-0.130 Paracetamol perioperatively achieve effective therapeutic within 1-2 timing coincident recovery phase short duration paediatric surgery. coefficient variance Cmax 43%. Some individual patients may not which therapeutic.