Phenotype modifications of T-cells and their shift toward a Th2 response in patients with systemic lupus erythematosus supplemented with different monthly regimens of vitamin D.

摘要: BackgroundVitamin D receptor is constitutively expressed on the lymphocyte surface. Recent studies highlight that vitamin may exert actions T-cells, inhibiting Th1 and Th17 response enhancing Th2 T-regulatory (T-reg) function.MethodsThirty-four patients with systemic lupus erythematosus (SLE) were randomly enrolled in a two-year prospective study. In first year, 16 supplemented an intensive regimen of cholecalciferol (IR) (300.000 UI at baseline 50.000 UI/monthly as maintenance, 850.000 UI annually), whereas 18 standard (SR) (25.000 UI monthly, 300.000 UI annually). During second switched to other arm treatment. Phenotypic analysis peripheral T quantification cytokine production from blood mononuclear cells (PBMCs) evaluated by flow cytometry.ResultsAt baseline, no significant difference between two groups emerged among main T-cell subtype...