How big is the financial burden of hepatitis B to society? A cost-of-illness study of hepatitis B infection in Singapore.

摘要: Hepatitis B virus (HBV) infection is the most common cause of chronic viral liver disease in Singapore. Nevertheless, very little data exist on financial burden HBV to society as a whole. The aim this study was therefore assess direct and indirect cost cost-of-illness analysis. combined from with estimated prevalence for different stages would represent annual Singaporean total its associated complications Singapore US$279 million (range US$34-941 when allowing various assumptions tested by sensitivity analyses), 58% or US$161 attributable cost. Based base-case estimation, alone equivalent 12% national healthcare expenditure 2003. incurred hepatitis patients represents biggest component, followed decompensated cirrhosis (DC) patients. ratio costs based estimation increased severity, highest obtained post-liver transplants (40.2:1), hepatocellular carcinoma (7.4:1) DC (2.7:1). results suggest that management poses more than medical challenge it sizeable economic both payer societal perspectives.