Factors that affect albumin concentration in dialysis patients and their relationship to vascular disease

摘要: Factors that affect albumin concentration in dialysis patients and their relationship to vascular disease. Introduction Hypoalbuminemia is a powerful risk factor for cardiovascular mortality hemodialysis (HD). Inflammation causes decrease synthesis an increase fractional catabolic rate, providing two mechanisms hypoalbuminemia. The inflammatory response alters the endothelium plasma protein composition ways favor injury. Plasma volume expanded HD patients, another mechanism Fibrinogen levels are independent disease (CVD) fibrinogen increased patients. expansion also CVD. Methods Albumin was measured 74 as disappearance of [ 125 I] human over six weeks. plasma. mass product volume. Results correlated positively with ( P Conclusion reduced part acute-phase HD. tends concentration, but elicits its rate synthesis, which, turn, associated levels. Thus, both inflammation factors reduce factors, independently