Y chromosome structural and functional changes in human malignant diseases.
作者： Néstor O Bianchi , None
DOI: 10.1016/J.MRREV.2009.02.001
关键词:
摘要: The main Y chromosome abnormalities found in testicular cancer and other malignant diseases are microdeletions, entire loss transcription deregulation of several genes mapping the non-recombinant part chromosome. Yet, role these changes origin or evolution malignancies is uncertain. has experienced a long intricate evolutionary history deleterious, compensatory, advantageous mutations. It proposed that compensatory mechanisms preventing decay cells no longer working, deletions gene down-expression reflect very fast process attrition. From this perspective, aberrations, mutations unbalanced expression likely play etiology cell transformation, although some forms cancer, may influence tumor progression.
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