Cardiovascular biomarkers and sex: the case for women
作者： Lori B. Daniels , Alan S. Maisel
DOI: 10.1038/NRCARDIO.2015.105
关键词:
摘要: Measurement of biomarkers is a critical component cardiovascular care. Women and men differ in their cardiac physiology manifestations disease. Although most are used by clinicians without taking sex into account, sex-specific differences clearly exist. Baseline concentrations many (including troponin, natriuretic peptides, galectin-3, soluble ST2) versus women, but these do not generally translate need for differential sex-based cut-off points. Furthermore, similarly diagnostic prognostic, regardless sex. Two potential exceptions troponins measured high-sensitivity assay, proneurotensin. Troponin levels lower women than and, with the use assays, points might improve diagnosis myocardial infarction. Proneurotensin novel biomarker that was found to be predictive incident disease men, also breast cancer. If confirmed, proneurotensin unique risk women. With any biomarker, an understanding its lead enhanced physiological between hearts
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