Genistein modulates the anti-tumor activity of cisplatin in MCF-7 breast and HT-29 colon cancer cells.
作者： Xiao-Juan Hu , Ming-Yong Xie , Felix M. Kluxen , Patrick Diel
DOI: 10.1007/S00204-013-1184-4
关键词:
摘要: The function of genistein (GEN) on tumor prevention and promotion is discussed controversially. A possible interference GEN with chemotherapy has been only rarely addressed so far. In this study, effects the anti-tumor activity cisplatin (CIS) were investigated in presence absence estradiol (10(-10) M) MCF-7 breast HT-29 colon cancer cells. Cells treated graded concentrations (10(-4)-10(-6) M), E2, CIS combinations. Cell growth, proliferation apoptosis determined as well expression level PCNA, Ki67 BCL-2 family members. 10(-4) M inhibited cell growth induced cells E2. Co-treatment 10(-4)M resulted additive effects. 10(-5) 10(-6) M, stimulated It promoted proliferation, counteracted Particularly ability to induce was antagonized. ER alpha-positive cells, but not alpha-negative E2 able neutralize anti-CIS GEN. Our data provide evidence that a situation which occurs postmenopausal women, directly affects cytostatic drugs like CIS. exact molecular mechanism be future studies.
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