Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application.

摘要: The intestinal epithelium is faced with the complex task of providing a barrier while also allowing nutrient and water absorption. frequency which these processes are disrupted in disease can be taken as evidence their importance. It therefore interest to define mechanisms altered transport function develop means correct disease-associated defects. Over past 10 years, some molecular events underlying physiological epithelial regulation have been described. Remarkably, recent advances shown that activation same central dysfunction both vitro vivo models disease. Although contribution pathogenesis chronic remains incompletely understood, it now clear cytoskeletal an important pathogenic process targeted inhibition myosin light chain kinase, affects this cytoskeleton-dependent tight junction dysfunction, attractive candidate for therapeutic intervention.