Dose-response analysis indicating time-dependent neurotoxicity caused by organic and inorganic mercury—Implications for toxic effects in the developing brain

摘要: A latency period preceding neurotoxicity is a common characteristic in the dose-response relationship induced by organic mercury. Latency periods have typically been observed with genotoxicants carcinogenesis, cancer being manifested long time after initiating event. These observations indicate that even very small dose may cause extensive adverse effects later life, so toxicity of genotoxic compound and time-dependent. In children, methylmercury exposure during pregnancy (in utero) has associated delays reaching developmental milestones (e.g., age at first walking) decreases intelligence, increasing severity exposure. Ethylmercury from thimerosal some vaccines associated, studies, autism other neurological disorders children. this paper, we examined whether data vitro vivo mercury studies fit Druckrey-Kupfmuller equation c·t(n)=constant (c=exposure concentration, t=latency period), established for carcinogens, or not irreversible are enhanced (n≥1), else toxic dose-dependent while only minor influence on outcome (n<1). The mode action underlying time-dependent binding to critical receptors causing cumulative effects. results describes well characteristics neurotoxic This amounts paradigm shift chemical risk assessment mercurial compounds highlights it vital perform testing geared investigate