Smooth muscle tumors of the gastrointestinal tract and retroperitoneum.A pathologic analysis of 100 cases

摘要: One hundred smooth muscle tumors arising in the gastrointestinal tract and retroperitoneum were reviewed an attempt to define criteria for diagnosis of leiomyosarcoma these sites. On basis aggressive behavior, 56 neoplasms diagnosed as leiomyosarcoma. Mitoses found be most useful indicator malignancy; all with five or more mitoses/10 HPF behaved aggressively this degree mitotic activity should A paucity mitoses, however, is no assurance benignity nearly 40% leiomyosarcomas series had fewer than HPF. Tumor cell necrosis was closely associated behavior even when mitoses infrequent it doubtful that benign develop extensive tumor necrosis. In absence requisite number necrosis, difficult distinguish some from leiomyomas, but size, cellularity cellular atypia may helpful parameters assessed together. The importance different anatomical sites discussed. It emphasized uterus do not apply non-uterine tumors. actuarial 2-year survival rate follows: gastric leiomyosarcoma, 40%; small intestinal 60%; retroperitoneal 16%.