Methods for site-specific drug conjugation to antibodies

摘要: Antibody drug conjugates (ADCs) are an emerging class of targeted therapeutics with the potential to improve therapeutic index over traditional chemotherapy. Drugs and linkers have been current focus ADC development, in addition antibody target selection. Recently, however,the importance conjugate homogeneity has realized. The methods for attachment lead a heterogeneous mixture, some populations that mixture poor vivo performance. New site-specific more homogeneous allow control site attachment. These subtle improvements can profound effects on efficacy index. This review examines conjugation antibodies, compares results their non-specifically conjugated counterparts. apparent improvement pharmacokinetics reduced off toxicity warrant further development this modification approach future development.