p53, p21 and p27 protein expression in head and neck cancer and their prognostic value.

摘要: Histological specimens from 62 laryngeal and 31 oral carcinomas were immunohistochemically assessed for p53, p21 p27 proteins; cases with > 10% labelled nuclei considered as positive. showed higher expression in patients 65-years-old (P = 0.04), chemotherapy responders 0.02), stage III longer overall survival representing the only independent prognostic factor multivariate analysis. In addition, p53-/p21+ longest whereas those p53+/p21- tumors shortest 0.02). A significant influence on of was also found combinations proteins p21+/p27- imparting best p21-/p27+ worst prognosis 0.04). significantly related to cancer 0.04) moderate high tumor grade 0.01). p53 not any examined clinicopathological characteristics. Our findings indicated that, by functionally promoting apoptosis, seems play a key role successful response may be predictive better head neck cancers.