Enantiomeric resolution of supramolecular helicates with different surface topographies

摘要: The enantiomeric resolution of an extended range di-metallo supramolecular triple-helical molecules are reported. ligands for all complexes symmetric with two units containing aryl group linked via imine bond to a pyridine. Alkyl substituents have been attached in different positions on the ligand backbone. Previous work parent compound, whose molecular formula is [Fe2(C25H20N4)3]Cl4, showed that it could be resolved into enantiomerically pure solutions using cellulose and 20 mM aqueous sodium chloride. In this mobile phases investigated see if separation speed elution increased amount NaCl co-eluted compounds decreased. Methanol, ethanol acetonitrile were considered, together : organic mixtures. Effective was most often achieved when 90% 10% (aq) w/v, which gives scope scaling up incorporate use HPLC. overall efficient (i.e. fastest) generally where column packed first eluted 100% acetonitrile, then 75% 25% until M enantiomer had fully finally P collected. sequence eluents ensured minimum accompanying enantiomers total solvent being required elute enantiomers, especially second one, from column. No helicate methyl groups pyridine rings also adverse effect resolution.