Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.
作者： John P Alao , Sona Michlikova , Peter Dinér , Morten Grøtli , Per Sunnerhagen
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摘要: Background The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of inhibitors with potent activity against RET. Herein, we have further investigated effect lead compound SPP86 on mediated signaling proliferation. Based these observations, hypothesized that may be useful for studying cellular
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