Copper-mediated aerobic iodination and perfluoroalkylation of boronic acids with (CF3)2CFI at room temperature
作者： Xi-Hai Liu , Jing Leng , Su-Jiao Jia , Jian-Hong Hao , Fanglin Zhang
DOI: 10.1016/J.JFLUCHEM.2016.07.021
关键词:
摘要: Abstract The copper-mediated aerobic reactions between the branched (CF3)2CFI and boronic acids (R-B(OH)2) are described. Different from linear perfluoroalkyl analogs CF3(CF2)nI (n = 2, 3, 5, 7), reacting with R-B(OH)2 at room temperature under air in presence of catalytic Cu powder provided exclusively corresponding iodides (R-I), while arylboronic Cu(OAc)2 gave perfluoroalkylation products (R-CF(CF3)2) acceptable to moderate yields. iodination reaction could be further promoted by hydroquinone, addition which improved oxidation ability ipso-iodination high was facilitated copper carboxylates since these salts into mixtures successfully give rise Ar-CF(CF3)2.
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