Are the WOSCOPS clinical and economic findings generalizable to other populations? A case study for Belgium. The WOSCOPS Economic Analysis Group. West of Scotland Coronary Prevention Study.

摘要: AIMS: As the West of Scotland Coronary Prevention Study (WOSCOPS) was conducted in Scotland, a country well-known for its high cardiovascular risk, generalizability findings on pravastatin's clinical and economic effects has been questioned. This study examines legitimacy this concern, using Belgium as case study. METHODS AND RESULTS: Local information prevalence clustering risk factors individual patients used equation to estimate reference Belgium. In contrast prevailing beliefs, shown coincide with trial population's risk. relative reduction documented should apply across populations, health benefits observed WOSCOPS can clearly be extrapolated. combination local costs then assess efficiency primary prevention pravastatin by means previously developed model. parallel original estimates United Kingdom, cost-effectiveness ratios remain well within range what is considered strong moderate evidence adoption appropriate utilization, over wide input values. CONCLUSION: demonstrates that from indeed generalized other populations.