Controlled local delivery of chemotherapeutic agents for treating solid tumors

摘要: A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the does not cross blood-brain barrier is characterized by poor bioavailability and/or short half-lives in vivo, are described. The consist reservoirs which release drug over an extended time period while at same preserving bioactivity agent. In most preferred embodiment, device consists biodegradable polymeric matrixes, although can also be formulated from non-biodegradable polymers or connected implanted infusion pumps. within immediately adjacent tumors treated site where they have been surgically removed. examples demonstrate efficacy paclitaxel camptothecin delivered implants prepared compression molding polymers, respectively. results highly statistically significant.