Elucidating the molecular architecture of adaptation via evolve and resequence experiments.

摘要: Evolve and resequence (E&R) experiments use experimental evolution to adapt populations a novel environment, then next-generation sequencing analyse genetic changes. They enable molecular be monitored in real time on genome-wide scale. Here, we review the field of E&R across diverse systems, ranging from simple non-living RNA bacteria, yeast complex multicellular organism Drosophila melanogaster. We explore how different evolutionary outcomes these systems are largely consistent with common population genetics principles. Differences explained by starting sizes, levels pre-existing variation, recombination rates adaptive landscapes. highlight emerging themes inconsistencies that future must address.