The role of androgen receptor CAG repeat polymorphism in androgen excess disorder and idiopathic hirsutism

摘要: The study aimed to investigate whether repeat number in the androgen receptor (AR) gene has any contribution phenotypes of disease excess (polycystic ovary syndrome (PCOS), idiopathic hyperandrogenemia (IHA) and hirsutism (IH) a cohort Turkish women. Three hundred fifty-four voluntary premenopausal women (172 healthy controls 182 patients with disorders hirsutism) 18–45 years age seen at an outpatient endocrine clinic Erciyes University Hospital between January 2013 December 2014 were included. All volunteers have undergone physical examination biochemical evaluation. polymorphic (CAG)n human AR was determined by fragment analyses. Detailed clinical analyses ended up 137 PCOS, 24 IHA, 21 IH. Pairwise comparisons revealed CAG differences PCOS (p = 0.005) IH (p = 0.020). Women length ≤ 17 had significantly increased twofold risk for than those with > 17 repeats OR: 2.0 (95% CI 1.2–3.3, p = 0.005). threefold 2.9 1.2–7.3, p = 0.020). When correlation analysis performed, weak negative detected short allele FGS score (r = − 0.131, p = 0.013) positive relationship total testosterone longer IHA group (r = 0.425, p = 0.039). Median length shorter oligomenorrhea woman normal menstrual cycle found be statistically significant (p = 0.017). This indicated that is associated inheritance ARs repeats.