Compositions for stimulating cd45 and thereby suppressing microglial activation associated with alzheimer's disease
作者： Michael Mullan , Jun Tan , Terrence Town
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摘要: A method of inhibiting the negative effects beta-amyloid in brain an animal comprising administering effective amount a compound that modulates CD45 activity. This invention also relates to compositions for use stimulating CD45, and assays une finding compounds useful beta-amyloid. An assay identifying inhibit comprises (a) contacting immune cells with predetermined one or more test presence peptides derived therefrom, (b) monitoring inflammatory molecules released by cells, (c) comparing found step another absence using different compounds.
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