Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
作者： Ralph B. Nielsen , Laura T. Mazzola , Dominique Charmot , Paul Mansky , Didier Benoit
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摘要: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided form polymer brushes, which comprise substrate having surface that is modified with water-dispersible or water-soluble segment functional groups bind probes. The method synthesis such sensors preferably includes use controlled free radical polymerization techniques allows architecture polymers to modify substrate. In this manner chain removed from surface, solution chemistry be more realistically reproduced benefits solid bound probe.
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