Making and Retaining New Memories: The Role of the Hippocampus in Associative Learning and Memory

摘要: The groundbreaking description of the amnesic patient H.M. in 1950s (Scoville and Milner 1957) demonstrated for first time that structures medial temporal lobe are critical our ability to learn retain new long-term memories facts events. This form memory is referred as declarative humans (Squire et al. 2004) relational animals (Eichenbaum 1999). development powerful animal models human amnesia monkeys (Zola-Morgan Squire 1990; Mishkin 1978; Zola 2000; Suzuki 1993) rodents (Bunsey Eichenbaum 1993,1995, 1996; Fortin 2002), together with detailed neuroanatomical studies (Suzuki Amaral 1994a,b; Burwell 1998a,b), definitively key important declarative/relational include hippocampus surrounding entorhinal, perirhinal parahippocampal cortices. While this convergence has provided information about pattern impairment following a wide range lesions lobe, less known how individual cells intact participate acquisition, consolidation or retrieval various forms memory.