Granulation in Miniaturised Fluid Bed Using Electrostatic Atomisation

摘要: Kivikero N., 2010. Granulation in Miniaturised Fluid Bed Using Electrostatic Atomisation. Dissertationes bioscientiarum molecularium Universitatis Helsingiensis Viikki, 10/2010 pp. 46. ISBN 978-952-10-6249-0 (paperback), 978-952-10-6250-6 (PDF), ISSN 17957079 The development of a new drug is extremely expensive and the process very slow, up to 15 years. Especially early formulation phase challenge for pharmaceutical industry, as amount active ingredient may only be few grams. A small should used produce much data rapidly possible. In this thesis, scale fluid bed device (Multipart Microscale powder Processor, MMFP) with electrostatic atomisation first time perform granulations. aims thesis were develop characterise suitable spraying method MMFP spray. parameters system granulation affecting granule size studied. Also applicability set-up studies was evaluated. found applicable spray production specially constructed nozzle. With particle tracking velocimetry, it possible generate droplet distributions produced high speed imaging provided information about liquid flow rate affected most, although voltage binder concentration had also an impact on it. provides possibilities study properties different materials sample size. screening are conducted. process, well following analysis fast, challenging traditional methods.