Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation

摘要: assigned to receive, during the postoperative period, either i.v. morphine 1 mg ml 21 or with ketamine for each. Morphine consumption was evaluated by cumulative doses every 12 h three days. Postoperative respiratory disorders were assessed spirometric evaluation and recording of nocturnal desaturation. Results. The adjunction resulted in a significant reduction as early 36th hour [43 (SD 18) vs 32 (14) mg, P¼0.03] similar visual analogue scale. In group, percentage time desaturation ,90% higher nights [1.80 (0.21‐6.37) 0.02 (0‐0.13), P,0.001; 2.15 (0.35‐8.65) 0.50 (0.01‐1.30), P¼0.02; 2.46 (0.57‐5.51) 0.55 (0.21‐1.00), P¼0.02]. decrease forced expiratory volume s less marked group at first day [1.04 (0.68‐1.22) litre 1.21 (1.10‐0.70) litre, P¼0.039]. Conclusions. Adding small PCA devices decreases may improve after thoracic surgery.