Novel pyrazole derivatives: synthesis and evaluation of anti-angiogenic activity.
作者： Michael S. Christodoulou , Sandra Liekens , Konstantinos M. Kasiotis , Serkos A. Haroutounian
DOI: 10.1016/J.BMC.2010.04.076
关键词:
摘要: The synthesis of a series novel trisubstituted pyrazole derivatives and their PIFA-mediated conversion to molecules bearing the fused pyrazolo[4,3-c]quinoline ring system is reported. anti-angiogenic activity these compounds was evaluated by using in vitro assays for endothelial cell proliferation migration, chicken chorioallantoic membrane (CAM) assay. Compounds containing motifs emerged as potent compounds, which also had ability inhibit growth human breast (MCF-7) cervical (Hela) carcinoma cells vitro.
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sci-hub.se 参考文章(21)
Anastasios Varvoglis, Hypervalent iodine in organic synthesis ,(1996)
Laurent F. Hennequin, Andrew P. Thomas, Craig Johnstone, Elaine S. E. Stokes, Patrick A. Plé, Jean-Jacques M. Lohmann, Donald J. Ogilvie, Mike Dukes, Steve R. Wedge, Jon O. Curwen, Jane Kendrew, Christine Lambert-van der Brempt, Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. Journal of Medicinal Chemistry. ,vol. 42, pp. 5369- 5389 ,(1999) , 10.1021/JM990345W
Laura Herm, Sándor Berényi, Argo Vonk, Ago Rinken, Attila Sipos, N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists. Bioorganic & Medicinal Chemistry. ,vol. 17, pp. 4756- 4762 ,(2009) , 10.1016/J.BMC.2009.04.047
Louis M. Sherwood, Edith E. Parris, Judah Folkman, Tumor Angiogenesis: Therapeutic Implications New England Journal of Medicine. ,vol. 285, pp. 1182- 1186 ,(1971) , 10.1056/NEJM197111182852108
Liang-Wen Zheng, Ling-Ling Wu, Bao-Xiang Zhao, Wen-Liang Dong, Jun-Ying Miao, Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells Bioorganic & Medicinal Chemistry. ,vol. 17, pp. 1957- 1962 ,(2009) , 10.1016/J.BMC.2009.01.037
Sandra Liekens, Ana-Isabel Hernández, Domenico Ribatti, Erik De Clercq, María-José Camarasa, María-Jesús Pérez-Pérez, Jan Balzarini, The Nucleoside Derivative 5′-O-Trityl-inosine (KIN59) Suppresses Thymidine Phosphorylase-triggered Angiogenesis via a Noncompetitive Mechanism of Action Journal of Biological Chemistry. ,vol. 279, pp. 29598- 29605 ,(2004) , 10.1074/JBC.M402602200
Christine Wasylyk, Hong Zheng, Christelle Castell, Laurent Debussche, Marie-Christine Multon, Bohdan Wasylyk, Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Research. ,vol. 68, pp. 1275- 1283 ,(2008) , 10.1158/0008-5472.CAN-07-2674
Gui-Feng Zhang, Kyung O. Johanson, Robert B. Kirkpatrick, Thau F. Ho, Paul W. Fisher, Michael R. Mattern, Randall K. Johnson, Michael J. Hansbury, James D. Winkler, Keith W. Ward, Daniel F. Veber, Scott K. Thompson, Lara S. Kallander, Qing Lu, Wenfang Chen, Thaddeus Tomaszek, Guang Yang, David Tew, Thomas D. Meek, Glenn A. Hofmann, Christina K. Schulz-Pritchard, Ward W. Smith, Cheryl A. Janson, M. Dominic Ryan, 4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo. Journal of Medicinal Chemistry. ,vol. 48, pp. 5644- 5647 ,(2005) , 10.1021/JM050408C
Fabio Carraro, Antonella Naldini, Annalisa Pucci, Giada A. Locatelli, Giovanni Maga, Silvia Schenone, Olga Bruno, Angelo Ranise, Francesco Bondavalli, Chiara Brullo, Paola Fossa, Giulia Menozzi, Luisa Mosti, Michele Modugno, Cristina Tintori, Fabrizio Manetti, Maurizio Botta, Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation. Journal of Medicinal Chemistry. ,vol. 49, pp. 1549- 1561 ,(2006) , 10.1021/JM050603R
Thomas Wirth, Hypervalent iodine chemistry in synthesis: scope and new directions. Angewandte Chemie. ,vol. 44, pp. 3656- 3665 ,(2005) , 10.1002/ANIE.200500115