Gene Deregulation and Chronic Activation in Natural Killer Cells Deficient in the Transcription Factor ETS1

摘要: Summary Multiple transcription factors guide the development of mature functional natural killer (NK) cells, yet little is known about their function. We used global gene expression and genome-wide binding analyses combined with developmental studies to unveil three roles for ETS1 factor in NK cells. functions at earliest stages cell promote critical transcriptional regulators including T-BET ID2, receptors (NKRs) NKp46, Ly49H, Ly49D, signaling molecules essential NKR As a consequence, Ets1 −/− NK cells fail degranulate after stimulation through activating NKRs. Nonetheless, these cells are hyperresponsive cytokines have characteristics chronic increased inhibitory NKRs multiple activation-associated genes. Therefore, regulates broad program that promotes target recognition while limiting cytokine-driven activation.