Arginine is a physiological precursor of endothelium-derived nitric oxide
作者： Harald H.H.W. Schmidt , Heinz Nau , Werner Wittfoht , Jörg Gerlach , Karl-Ernst Prescher
DOI: 10.1016/0014-2999(88)90101-X
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摘要: ATP dose dependently stimulated the formation and release of nitric oxide (NO) from perfused rabbit aorta. L-Canavanine, an inhibitor various L-arginine-utilizing enzymes, abolished basal ATP-induced NO release. increased accumulation presumably NO-derived NO2- in medium primary cultures bovine aortic endothelial cells. 15NO, 15NO2- 15NO3- was found when L-[guanido-15N2]arginine added to culture medium. We conclude that terminal guanidino nitrogens L-arginine are physiological precursors endothelium-derived NO.
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