Apigenin, A Plant Flavone Playing Noble Roles in Cancer Prevention Via Modulation of Key Cell Signaling Networks.

摘要: Background Cancer is a global health problem and the continuous rise in incidence mortality due to cancer carries real economic burden all countries. Accumulation of genetic mutation, exposure environmental carcinogens food habits change lifestyles are key reasons for cancer. Targeting cells, we need multitargeting molecule with low/no toxicity. Objective To review current update research status chemopreventive/therapeutic molecule, Apigenin. Methods Compare results published articles granted patents on this compound. We also discuss pros cons present future direction. Results cells have characteristic alterations dysregulation various cell signaling pathways that control homeostasis, proliferation, motility, survival normal cells. Natural flavonoids compounds well known their anti-inflammatory, anti-oxidant, anti-cancerous properties. Apigenin, along several other physiological effects, has very low intrinsic toxicity striking effects proliferation Interestingly, getting wide acceptance among researchers. It evident from recent filed At present, three been only anticancer properties apigenin. Conclusion This mini-review will explain apigenin further shine some light how performs its actions by interfering cellsignaling pathways.