Metabolism of high density lipoproteins by the perfused rabbit liver.

摘要: The role of the liver in catabolism high density lipoproteins (HDL) was examined isolated perfused rabbit livers. Using 125I-labeled HDL disappearance labeled apolipoproteins from perfusate biphasic with 7% label removed after 20 min and a further 6% between 90 min. In contrast, [3H]cholesteryl esters 35% had been effect perfusion on size composition studied by recirculating for 120 control experiments incubated at 37 degrees C nonperfused media that perfused. added predominantly particles 4.8-4.9-mm radius, incubation preperfused produced no significant change size. However, resulted 4.2-4.3-mm radius. Hepatic also significantly reduced cholesteryl ester as percentage mass 13.3 +/- 2.2% incubations to 10.7 3.1% (p less than 0.001), ester:protein ratio 0.31 0.06 0.24 0.10 0.001) perfusion. Thus interaction results smaller depleted core esters.