Possible role of plasmacytoid dendritic cells in pityriasis lichenoides.

摘要: Background Plasmacytoid dendritic cells (pDCs) and their product, type I interferons (IFNs), have been implicated in the pathogenesis of several skin disorders characterized by an interface dermatitis (ID) pattern, such as lichen planus (LP). A IFN signature has previously documented pityriasis lichenoides (PL). Although pDCs are known to be main source most potent producers local IFNs, role PL not investigated. Aim To investigate PL. Methods In total, 20 cases comparable LP were immunohistochemically tested for pDC occurrence production using anti-blood-derived cell antigen-2 (BDCA2; a specific marker) anti-myxovirus protein (anti-MxA) antibodies (indirect marker activity), respectively. MxA is well-established surrogate 1 production. semiquantitative scoring system was used. Results present all 40 with no statistically significant difference between two groups. expression intense diffuse majority cases. Conclusions constitute central component inflammatory infiltrate PL, suggesting that shares other entities exhibit ID common pDC-driven process through production, which ultimately leads cytotoxic attack.