Prognostic factors in elderly women with metastatic breast cancer treated with tamoxifen : an analysis of patients entered on four prospective clinical trials

摘要: BACKGROUND Information regarding prognostic factors and survival in elderly women with metastatic breast cancer treated tamoxifen is limited. METHODS The data from 4 prospective clinical trials were analyzed, including information on 396 postmenopausal advanced who received as initial therapy for disease. Emphasis was placed 184 patients (age greater than 65 years) to characterize the response therapy, time progression (TTP), overall (OS), factors, treatment-related toxicity. RESULTS Among 363 measurable or evaluable disease, objective rates higher (46% versus 33%, P = 0.06); but age did not achieve significance a logistic regression analysis (P 0.1). The median TTP (10.5 months 6.2 months, log rank 0.002) OS (35.7 28.8 0.02) superior cohort. In multivariate analysis, at diagnosis approached statistical 0.055) significant 0.17). Among patients, disease free interval (DFI) (greater 5 years), dominant site (soft tissue), prior adjuvant chemotherapy, positive estrogen/progesterone receptor (ER/PgR) performance status (PS) independent factors. Hot flashes common both younger older cohorts (25% 0.14), while anorexia (14% 22%, 0.04) mood changes (2% 6%, 0.03) more patients. CONCLUSIONS There no indication that have poorer outcome regard rate, OS; fact, they appeared slightly better prognosis although this after adjustment other DFI, PS, ER PGR, are Cancer 1996; 77:683-90.