Antioxidant Saffron and Central Retinal Function in ABCA4-Related Stargardt Macular Dystrophy.

摘要: Retinal oxidative damage, associated with an ATP-binding cassette, sub-family A, member 4, also known as ABCA4 gene mutation, has been implicated a major underlying mechanism for Stargardt disease/fundus flavimaculatus (STG/FF). Recent findings indicate that saffron carotenoid constituents crocins and crocetin may counteract retinal inflammation protect cells from apoptosis. This pilot study aimed to evaluate central function following supplementation in STG/FF patients carrying mutations. Methods: randomized, double-blind, placebo-controlled (clinicaltrials.gov: NCT01278277), 31 ABCA4-related visual acuity >0.25 were randomly assigned assume oral (20 mg) or placebo over six month period then reverted P S further period. Full ophthalmic examinations, well 18° focal electroretinogram (fERG) recordings, performed at baseline after months of either placebo. The fERG fundamental harmonic component was isolated by Fourier analysis. Main outcome measures amplitude (in µV) phase degrees). secondary measure acuity. Results: supplement tolerated all throughout follow-up. After saffron, unchanged; placebo, tended decrease (mean change: −0.18 log µV, p < 0.05). Reverting the treatments, did not change significantly. unchanged Conclusions: short-term had no detrimental effects on electroretinographic responses retina current warrant long-term clinical trials assess efficacy slowing down progression dysfunction STG/FF.