Effect of Ketoconazole on the Pharmacokinetic Profile of Buprenorphine following Administration of a Once-Weekly Buprenorphine Transdermal System
作者： Ram P. Kapil , Alessandra Cipriano , Gregory H. Michels , Peter Perrino , Sarah A. O’Keefe
DOI: 10.1007/BF03261913
关键词:
摘要: Background and Objective: Buprenorphine is extensively metabolized by cytochrome P450 (CYP) 3A4. This study evaluated the effect of ketoconazole, a CYP3A4 inhibitor, on metabolism buprenorphine following administration transdermal system 10μg/hour (BTDS 10).
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